Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people.

TitleAbsence of neurocognitive effect of hepatitis C infection in HIV-coinfected people.
Publication TypeJournal Article
Year of Publication2015
AuthorsClifford, DB, Vaida, F, Kao, Y-T, Franklin, DR, Letendre, SL, Collier, AC, Marra, CM, Gelman, BB, McArthur, JC, Morgello, S, Simpson, DM, Grant, I, Heaton, RK
Corporate AuthorsCHARTER Group
JournalNeurology
Volume84
Issue3
Pagination241-50
Date Published2015 Jan 20
ISSN1526-632X
KeywordsAdult, Anti-HIV Agents, CD4-Positive T-Lymphocytes, Cognition Disorders, Cohort Studies, Female, Hepacivirus, Hepatitis C, HIV, HIV Infections, Humans, Male, Middle Aged, Neuropsychological Tests, Serologic Tests, United States, Viral Load
Abstract

OBJECTIVE: To investigate the effect of hepatitis C virus (HCV) on neurocognitive performance in chronically HIV-infected patients enrolled in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) study.

METHODS: A total of 1,582 participants in CHARTER who were tested for HCV antibody underwent neurocognitive testing; serum HCV RNA was available for 346 seropositive patients. Neurocognitive performance was compared in 408 HCV-seropositive and 1,174 HCV-seronegative participants and in a subset of 160 seropositive and 707 seronegative participants without serious comorbid neurologic conditions that might impair neurocognitive performance, using linear regression and taking into account HIV-associated and demographic factors (including IV drug use) and liver function.

RESULTS: Neurocognitive performance characterized by global deficit scores and the proportion of individuals who were impaired were the same in the HCV-seropositive and HCV-seronegative groups. In univariable analyses in the entire sample, only verbal domain scores showed small statistically different superior performance in the HCV+ group that was not evident in multivariable analysis. In the subgroup without significant comorbidities, scores in all 7 domains of neurocognitive functioning did not differ by HCV serostatus. Among the HCV-seropositive participants, there was no association between neurocognitive performance and serum HCV RNA concentration.

CONCLUSION: In HIV-infected patients, HCV coinfection does not contribute to neurocognitive impairment, at least in the absence of substantial HCV-associated liver damage, which was not evident in our cohort.

DOI10.1212/WNL.0000000000001156
Alternate JournalNeurology
PubMed ID25503616
PubMed Central IDPMC4335996
Grant ListHHSN271201000030C / / PHS HHS / United States
HHSN271201000036C / / PHS HHS / United States
N01 MH22005 / MH / NIMH NIH HHS / United States
P30 MH062512 / MH / NIMH NIH HHS / United States
P30 MH075673 / MH / NIMH NIH HHS / United States