CHARTER Studies
The following studies have been approved to use CHARTER resources, and may be ongoing or completed.
| Principal Investigators | Site | Project Title | Approval Date |
| Mariana Cherner | UCSD | Neurocognitive Consequences of IL6 Modulation by Marijuana | 12/10/2014 |
| Lance Bauer | University of CT School of Medicine | Prediction of ART Non-Adherence: A Candidate Gene Analysis | 12/2/2014 |
| Zhixin Zhang | University of Nebraska Medical Center | Anti-NMDAR Antibodies in HIV Patients Contribute to Neurocognitive Disorders | 11/26/2014 |
| Andrea Calcagno | University of Torino | Abacavir and Lamivudine Exposure in the Cerebrospinal Fluid of HIV-positive Patients: Impact Once-daily versus Twice-daily Administration | 11/24/2014 |
| Italo Mochetti | Georgetown University Medical Center | Allele Polymorphism in TrkB in Association with HIV-mediated Depression. | 11/4/2014 |
| Fred Sattler/Allen McCutchan | USC/UCSD | Relationship of NCI and Metabolic Variables by Sex and Obesity | 9/10/2014 |
| Todd Hulgan | Vanderbilt University | Supplemental Project: Iron and Mitochondrial Genomics in Neuro-inflammation and HAND: A CHARTER Study | 8/15/2014 |
| Mario Bianchet | Johns Hopkins School of Medicine | Genetic Association between Antioxidant-Response Defects and HAND | 3/14/2014 |
| Gabriel Wagner | UCSD | HIV Dual Infection and Neurocognitive Impairment | 12/4/2013 |
| Mariana Cherner | UCSD | Genetics of Methamphetamine Metabolism and Cognitive Impairment in HIV | 8/22/2013 |
| Fred Sattler/Allen McCutchan | USC/UCSD | Role of Central Obesity and Inflammation in the Pathogenesis in HIV-Associated Neurocognitive Disorder (HAND) in Patients on Successful ART: A Concept Proposal to Generate Data for an RO1 Application | 8/20/2013 |
| Maria Marquine | UCSD | Neurocognitive Impairment in HIV-infected Hispanics | 8/20/2013 |
| Edward Hammond | Johns Hopkins Bloomberg School of Public Health | Supplement - Cytokines and Chemokines Mediating Depression and Dementia in HIV | 8/6/2013 |
| John Keltner/David Miller/Colm Connolly/Michael Lee | UCSD/PA Dept Electrical Engineering and Computer Science/UCSF/Oxford University Pain Relief Unit | Machine Learning and Voxel Based Morphometric Analyses of Multi-modal Neuroimaging of HIV Distal Neuropathic Pain | 6/6/2013 |
| Ahson Ghias | UCSD | Association of Vascular and Metabolic Risk Factors with Neurocognitive Decline in HIV Patients | 5/15/2013 |
| Marie-Josee Brouillette | McGill University Health Centre | Development of Risk index for Congnitive Decline | 5/15/2013 |
| Emily Trepasso Grullon | California School of Professional Psychology | Neuropsychological Functioning, Depression, and Vocational Performance Among a Sample of HIV-Positive Individuals | 3/12/2013 |
| Howard Fox | U Nebraska Med Ctr | Methylome in HIV infection - Signs of Accelerated Aging | 3/3/2013 |
| Kamel Khalili | Temple University | Identification of Biomarkers for HAND | 2/8/2013 |
| Suzi Hong | UCSD | Association Between Blood Pressure and Neurocognitive Function in HIV+ individuals | 1/31/2013 |
| Magnus Gisslen | U of Gothenburg | Signs of Axonal Injury in HIV-infected Subjects on Suppressive Antiretroviral Treatment with ANI/MND | 1/7/2013 |
| Fred Sattler | USC | Role of Central Obesity and Inflammation in the Pathogenesis in HIV-Associated Neurocognitive Disorder (HAND) in Patients on Successful ART: A Concept Proposal to Generate Data for an RO1 Application | 9/6/2012 |
| Asha Kallianpur | Cleveland Clinic Foundation | Genetic Associations with Quantitative Structural and Metabolite Neuroimaging Endophenotypes in CHARTER | 7/23/2012 |
| Benedict Michael | Institute of Infection & Global Health | Identification and Validation of Diagnostic and Prognostic Matrices of Clinical Features and Cerebrospinal Fluid and Serum Biomarkers for HIV Associated Neurocognitive Impairment | 7/23/2012 |
| Andrea Hobkirk | U of Albany | Does Depression Create Impairment Via Immune Function? | 4/20/2012 |
| Namandje Bumpus | JHU | Evaluation of the Correlation between Efavirenz Neurotoxicity and Efavirenz Metabolite Concentrations in CSF and Plasma | 4/16/2012 |
| Farrah Jasmine Mateen | JHU | Telomere Length as a Putative Biomarker of Human Immunodeficiency Virus-Associated Cognitive Impairment | 4/1/2012 |
| Ignacio Perez-Valero | UCSD | Neurocognitive Evolution of HIV-suppressed Participants Effectively Treated with a NNRTI-based or a PI-based Conventional HAART | 3/21/2012 |
| Sanjay Mehta | UCSD | Relationship of Mitochondrial Haplotype and HAND | 3/21/2012 |
| Jonathan Ipser | UCSD | Investigating Age and Cognitive Reserve as Moderators of the Association between HIV-associated Neurocognitive and Functional Impairment | 3/16/2012 |
| Jennifer McGuire | Children's Hospital of Philadelphia | Central and Peripheral Biomarkers of Neurodegeneration Across the Spectrum of HAND | 3/14/2012 |
| Jiah Pearson-Leary | U of Albany | HIV Protease Inhibitors that Block Intrinsic Activity of Insulin-regulated Glucose Transporter-4: Is there a Role for Insulin Resistance in Neurobehavioral and Structural Temporal Lobe Deficits of HIV Patients? | 1/25/2012 |
| Tricia Burdo | Boston College | Elevated sCD163 is a Marker of Neurocognitive Impairment in HIV-infected Individuals on Effective ART. | 11/23/2011 |
| Ignacio Perez Valero | UCSD | Validation of the EACS Screening Tool to Predict HIV-associated Neurocognitive Disorders in the CHARTER Cohort | 11/8/2011 |
| Maria Ferrara | UCSD | Effect of Second Generation Antipsychotics (SGA) and Mood Stabilizers (MS) on Metabolic Syndrome (MetS) Components in HIV Positive People on Long-term Antiretroviral Therapy. | 10/12/2011 |
| Ignacio Perez Valero | UCSD | Factors Associated with Viral Escape in the CSF | 10/11/2011 |
| Kumud Singh | UCSD | Role of Complement Activation Pathway Gene Variations in HIV Related Neurocognitive Impairment | 10/1/2011 |
| Christina Marra | Harborview Medical Center | Neurocognitive Impairment in Incident Syphilis in CHARTER | 9/15/2011 |
| Derek Blechinger | Harborview Medical Center | HIV and Asymptomatic Neurosyphilis: A Closer Look | 7/21/2011 |
| Elizabeth Harlan Michelle | JHU | The Effect of Viral Load on Neurocognitive Outcomes in Neurocognitively Impaired HIV-infected Individuals | 6/23/2011 |
| Maiko Sakamoto | UCSD | Utility of the HIV Dementia Scale (HDS) and Adjunctive Biological Markers for Detecting HIV-associated Neurocognitive Impairment | 6/6/2011 |
| Nell Lurain/Alan Landay | Rush University | The Impact of Cytomegalovirus Reactivation on Neurocognitive Performance in People Living with HIV Disease | 3/4/2011 |
| Susumu Mori | JHU | Characterization of Anatomical Features of HAND Patients Using MRI/DTI Data | 1/10/2011 |
| Kaitlin Blackstone | UCSD | Sensitivity and Specificity of Self-report Versus Performance-based Measures of Everyday Functioning in Diagnosing HIV-related Neurocognitive Disorders | 11/3/2010 |
| Kaitlin Blackstone | UCSD | Deficit Scores Versus Clinical Ratings: Defining Neurocognitive Impairment in HIV | 11/3/2010 |
| Davey Smith | UCSD | A Multi-site Investigation into the Effect of HIV Clade on Neurocognitive Impairment | 10/12/2010 |
| John Keltner | UCSD | Structural Neuroimaging Correlates for Depression and HIV Neuropathy from the CHARTER cohort | 7/18/2010 |
| John Keltner | UCSD | Differential Multidimensional Clinical Outcomes in HIV Neuropathy in the CHARTER Cohort | 7/18/2010 |
| Edward Hammond | JHU | The Effects of Central Nervous System Penetration Effectiveness of HAART on Depression and CSF/Blood Pro-Inflammatory Cytokines in Persons Infected with HIV | 6/24/2010 |
| Cristian Achim | UCSD | Data Mining of the CHARTER 500 GWAS Results to Explore the Association between immunophilin Genes Polymorphisms and HAND | 4/22/2010 |
| Christine Fennema-Notestine | UCSD | Multi-Modal Imaging Signatures of Abnormal Tissue for Enhanced Characterization of HIV Neuropathogenesis | 4/22/2010 |
| Todd Hulgan | Vanderbilt | Mitochondrial-Nuclear Gene-Gene Interactions and HIV-associated Distal Sensory Peripheral Neuropathy in CHARTER | 4/22/2010 |
| Cinnamon Bloss | Scripps | Genome-Wide Association Analyses of Neurocognitive Phenotypes in HIV | 4/8/2010 |
| Doyle Patton | Childrens Diagnostic & Treatment Ctr | Medication Management Capacity, Neurocognitive Functioning and Antiretroviral Adherence in Adults with HIV Infection | 3/11/2010 |
| Asha Kalianpur | Vanderbilt | Iron-Regulatory Pathway Variation in Neurological Complications of HIV and HIV Therapy: Results from the CHARTER Genome-Wide Association Study | 9/10/2009 |
| Kamud Singh | UCSD | Mannose Binding Lectin in Neuroinflammation and NeuroAIDS | 9/10/2009 |
| Teresa Evering | Aaron Diamond AIDS Research Ctr | Phylogenetic and Functional Examination of CSF-derived HIV-1 | 8/27/2009 |
| Joan Berman | Albert Einstein | The Role of Soluble CD40 Ligand (sCD40L) as a Predictor of HIV Dementia | 8/17/2009 |
| Ian Everall | UCSD | MDD/Candidate Genes | 7/28/2009 |
| Ian Everall | UCSD | MDD/Candidate Genes | 7/28/2009 |
| Erin Morgan | UCSD | Effect of APOE Genotype on Neurocognitive Impairment in HIV | 6/25/2009 |
| George Hightower | UCSD | Neutralizing Antibody and Cytotoxic T lymphocyte Responses Determining Compartmental HIV Evolution in Blood and CSF from Chronically Infected Individuals | 6/11/2009 |
| Christine Fennema-Notestine | UCSD | Comparison of Anatomical Labeling Methods for Subcortical Volumes in HIV: Methodological Study and Addition to the CHARTER Resource | 2/26/2009 |
| Jayraan Badiee | UCSD | Suicidality and Neuropsychological Impairment among HIV-Infected Persons | 2/26/2009 |
| Jessica Robinson-Papp | MSSM | Race, Ethnicity and HIV-associated Distal Sensory Polyneuropathy | 12/11/2008 |
| David Simpson | MSSM | The Effect of Enzyme-inducing Antiepileptic Agents on Patients Clinical Responses to NNRTI-containing Antiretroviral Regimens | 12/11/2008 |
| Sunhee Lee | AECM | Macrophage Insulin-like Growth Factor 1 (IGF1) During HIV infection | 11/13/2008 |
| Dana Gabuzda | DFCI | LPS and Monocyte Activation in HIV-associated Neurocognitive Disorders | 8/14/2008 |
| David Moore | UCSD | Medication Adherence, ART Resistance, and Neuropsychological Impairment Among HIV-Infected Persons with Virologic Failure | 6/26/2008 |
| George Fein | NRI | Automated Delineation and Quantification of White Matter Signal Hyperintensities | 4/24/2008 |
| Linda McEvoy | UCSD | Neural Markers of Executive Dysfunction in HIV: Evidence from Magnetoencephalography and Magnetic Resonance Imaging | 12/13/2007 |
| Laura Baldassari | JHU | Oxidative Stress Markers in HIV-associated Neurocognitive Disorders and Stroke | 12/13/2007 |
| Paul Nyquist | JHU | Host Genetics, Neuropathy, and Dementia | 1/11/2007 |
| Ian Everall | UCSD | Gene Expression in Major Depressive Disorder | 11/9/2006 |
| Rachel Schrier | UCSD | Examination of CSF Cell Integrity | 11/9/2006 |
| Reuben Robbins | MSSM | Cultural and Neuropsychological Predictors of Medication Adherence Among HIV+ Hispanics | 10/26/2006 |
| David Clifford | Wash U. | Study of the Natural History of HIV/AIDS in the Era of Effective Therapy (Sun) | 9/14/2006 |
| Davey Smith | UCSD | Neuropsychological Impairment During Acute and Early HIV Infection | 8/24/2006 |
| Beau Ances | UCSD | Calibrated BOLD fMRI of HIV-associated Neurocognitive Impairment | 8/24/2006 |
| Brian Schweinsburg | UCSD | Diffusion Tensor Imaging | 8/10/2006 |
| Terry Jernigan | UCSD | Role of Evolving White Matter Damage in Neurocognitive Effects of HIV and HCV | 3/9/2006 |
| Reon Baird | MSSM | Quality of Education Substudy | 3/9/2006 |
| Bipasha Biswas | Wash U | Neurocognitive and Psychosocial Factors Associated with Antiretroviral Therapy Adherence among Men and Women living with HIV/AIDS | 2/23/2006 |
| David Clifford | Wash U | Amyloid in HIV Associated Cognitive Disorders | 1/12/2006 |
| Justin McArthur/Adriana Andrade | UW, JHU | Effect of Neurocognitive Function, Depression, and Functional Status on Antiretroviral Medication Adherence | 1/12/2006 |
| Assawin Gongvatana | UCSD | Microstructural White Matter Integrity in HIV-infected Individuals in the HAART Era: A Diffusion Tensor Imaging Study | 12/8/2005 |
| Debra Henninger | MSSM | Ecological Validity of Neuropsychological Assessment: The Roles of Vocational Assessment and Employment in Aging HIV+ Adults | 12/8/2005 |
| Jeanne Huang | UCSD | Leptin and HIV-Associated Neurocognitive Impairment | 12/8/2005 |
| Anita Venkataramana | JHU | Relationship of the GDS and the HDS and IHDS | 5/12/2005 |
| Kirk Sperber | MSSM | Induction of Apoptosis by HIV-1 Infected Monocytic Cells | 10/14/2004 |
