CHARTER ENROLLMENT (2003-2007)
CHARTER recruited ~1600 HIV-infected participants at varying stages of disease and with differing histories of antiretroviral treatment into the Cross-sectional Study. Participants in this study received comprehensive neuromedical and neurobehavioral assessments.
In addition a subset of 652 participants entered a Longitudinal Pathogenesis Study and were evaluated semi-annually. The cases were selected on the basis of identified groups of interest (defined as groups of participants with characteristics whose long term follow-up would shed additional light on important questions in regard to neuroAIDS in the era of HAART).
|CHARTER Enrollment by Performance Site||Participant Groups|
OPTION PERIOD COHORT (2007-2010)
300 participants (50 per site) were selected from the Longitudinal Study (N=600). Assessments will occurred every six months. This cohort was selected to address aims related to host genetics, viral genetics, worsening peripheral neuropathy, and progression of abnormal white matter.
|Number of Subjects and Visits in Option Years 6-8|
|YEAR 6||YEAR 7||YEAR 8|
|Visits across all sites||577||490||417|
|Visits per site||96||82||69|
|Subjects at beginning of each year
(adjusting for anticipated attrition)