Cohort Description
CHARTER ENROLLMENT (2003-2007)
CHARTER recruited ~1600 HIV-infected participants at varying stages of disease and with differing histories of antiretroviral treatment into the Cross-sectional Study. Participants in this study received comprehensive neuromedical and neurobehavioral assessments.
In addition a subset of 652 participants entered a Longitudinal Pathogenesis Study and were evaluated semi-annually. The cases were selected on the basis of identified groups of interest (defined as groups of participants with characteristics whose long term follow-up would shed additional light on important questions in regard to neuroAIDS in the era of HAART).
| CHARTER Enrollment by Performance Site | Participant Groups |
|---|---|
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OPTION PERIOD COHORT (2007-2010)
300 participants (50 per site) were selected from the Longitudinal Study (N=600). Assessments will occurred every six months. This cohort was selected to address aims related to host genetics, viral genetics, worsening peripheral neuropathy, and progression of abnormal white matter.
| Number of Subjects and Visits in Option Years 6-8 | |||
| YEAR 6 | YEAR 7 | YEAR 8 | |
| Visits across all sites | 577 | 490 | 417 |
| Visits per site | 96 | 82 | 69 |
| Subjects at beginning of each year (adjusting for anticipated attrition) |
300 | 255 | 217 |
