Persistent HIV in the central nervous system (CNS) during treatment is associated with worse antiretroviral therapy (ART) penetration and cognitive impairment.

Type: Poster
Title: Persistent HIV in the central nervous system (CNS) during treatment is associated with worse antiretroviral therapy (ART) penetration and cognitive impairment.
Authors: Letendre S, McClernon D, Ellis RJ, Munoz-Moreno J, Way L, Clifford D, Collier A, Gelman B, Marra C, McArthur J, McCutchan A, Morgello S, Simpson D, Franklin D, Heaton R, Grant I, and the CHARTER Group
Date: 02-08-2009
Abstract:"Background: Cognitive impairment can occur or persist during ART. Explanations include co-morbidities, neurotoxic ART, persistent neuroinflammation, or persistent HIV replication. This analysis assessed whether low levels of HIV in CSF were associated with inter-individual differences in ART and neuropsychological (NP) performance.