White matter damage and cortical volume loss affect different cognitive and motor functions in HIV-infected individuals.

Type: Published Abstract
Title: White matter damage and cortical volume loss affect different cognitive and motor functions in HIV-infected individuals.
Authors: Jernigan TL, Archibald SL, Taylor MJ, Woods SP, Abramson I, Clifford D, Collier A, Ellis RJ, Gamst AC, Gelman BB, Heaton R, Letendre S, Marcotte T, Marra C, McArthur JC, McCutchen JA, Morgello S, Simpson D, Grant I
Year: 2008
Publication: Journal of the International Neuropsychological Society
Volume: 14 Issue: Suppl. 1 Pages: 243
Abstract:Some HIV-seropositive (HIV+) individuals develop clinically significant cognitive impairment that in some cases progresses to dementia. The pattern of deficits observed is variable, but among the most prominent are motor and psychomotor slowing, attention and executive deficits, and inefficient learning. The neural basis for this heterogeneity is poorly understood.